Role of SH3GLB1 in the regulation of CD133 expression in GBM cells
Abstract Background Glioblastoma (GBM), a malignant brain tumor, has poor survival outcomes due to recurrence or drug resistance.We found that SH3GLB1 is a crucial factor for cells to evade temozolomide (TMZ) cytotoxicity through autophagy-mediated oxidative phosphorylation, which is abc material associated with CD133 levels.Therefore, we propose t